abstract：:Total beta-adrenoceptor density and beta 1- and beta 2-subtype distribution in right and left atria and in different ventricular regions from 14 failing and seven nonfailing human hearts have been compared. End-stage heart failure was due to idiopathic dilated cardiomyopathy (n = 8) or ischaemic cardiomyopathy (n = 6)...

journal_title：European journal of clinical pharmacology

authors： Steinfath M,Lavicky J,Schmitz W,Scholz H,Döring V,Kalmár P

更新日期：1992-01-01 00:00:00

abstract：:Of 23 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose fasting blood glucose had not reached less than or equal to 6.0 mmol.l-1 after 10 weeks of dietary regulation, 15, who had had a weight reduction of -2.8 kg by dietary control, did achieve a fasting blood glucose less than or equal to 6.0 mmol....

journal_title：European journal of clinical pharmacology

authors： Bitzén PO,Melander A,Scherstén B,Svensson M,Wåhlin-Boll E

更新日期：1992-01-01 00:00:00

abstract：:Blood levels of racemic chloroquine and its main metabolites desethylchloroquine and bisdesethylchloroquine were measured in 29 patients treated chronically for rheumatoid arthritis. In six patients, the concentrations were followed during a one day dosage interval. There was considerable intersubject variability in t...

journal_title：European journal of clinical pharmacology

authors： Augustijns P,Geusens P,Verbeke N

更新日期：1992-01-01 00:00:00

abstract：:Glycerol 50 g infused i.v. over 2 to 6 h is widely used to treat cerebral oedema in patients with acute stroke. Its transit through the blood-cerebrospinal fluid barrier in subjects with uninflamed meninges has now been examined. In 7 patients with an external ventriculostomy for occlusive hydrocephalus, each of whom ...

journal_title：European journal of clinical pharmacology

authors： Nau R,Prins FJ,Kolenda H,Prange HW

更新日期：1992-01-01 00:00:00

abstract：:We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment). The apparent systemic clearance of methotrexate was significantly reduced by all three treatments. Tri...

journal_title：European journal of clinical pharmacology

authors： Tracy TS,Krohn K,Jones DR,Bradley JD,Hall SD,Brater DC

更新日期：1992-01-01 00:00:00

abstract：:The pharmacokinetics of temocapril hydrochloride, a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, has been studied in patients with mild (Group II) to severe (Group III) renal insufficiency in comparison with subjects with normal renal function (Group I). The pharmacokinetic parameters of the act...

journal_title：European journal of clinical pharmacology

authors： Nakashima M,Yamamoto J,Shibata M,Uematsu T,Shinjo H,Akahori T,Shioya H,Sugiyama K,Kawahara Y

更新日期：1992-01-01 00:00:00

abstract：:We gave 24 healthy elderly volunteers with a perceived sleep onset of at least 30 minutes zolpidem 5 mg, zolpidem 10 mg, or placebo for 7 days in a double-blind, three-way, crossover study. The morning after nocturnal dosing, psychomotor performance and cognitive ability were measured using tests which are sensitive t...

journal_title：European journal of clinical pharmacology

authors： Fairweather DB,Kerr JS,Hindmarch I

更新日期：1992-01-01 00:00:00

abstract：:The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 2...

journal_title：European journal of clinical pharmacology

authors： Leroy A,Fillastre JP,Etienne I,Borsa-Lebás F,Humbert G

更新日期：1992-01-01 00:00:00

abstract：:The effect of drinking grapefruit juice on the acute pharmacokinetic and haemodynamic actions of the dihydropyridine calcium antagonist felodipine given as a 5 mg plain tablet has been studied in nine, healthy, middle-aged males. Compared to water, grapefruit juice caused an increase in Cmax from mean 6 to 16 nmol.l-1...

journal_title：European journal of clinical pharmacology

authors： Edgar B,Bailey D,Bergstrand R,Johnsson G,Regårdh CG

更新日期：1992-01-01 00:00:00

abstract：:There are many questions concerned with therapy and its application. Depending on the perspective of the study there can be several "populations" which, when considered individually, may give different, or even inconsistent conclusions. These populations are: the sick population, the therapist's target population, the...

journal_title：European journal of clinical pharmacology

authors： Collet JP,Boissel JP

更新日期：1991-01-01 00:00:00

abstract：:The effect of AS-4370 on gastric emptying was investigated in healthy adults using 99mTc-DTPA. Single doses of AS-4370 2.5, 5 or 10 mg or placebo were administered to 12 subjects in a controlled, double-blind, cross-over study. Tests were performed twice weekly in each subject. Thirty min after administration of test ...

journal_title：European journal of clinical pharmacology

authors： Kanaizumi T,Nakano H,Matsui Y,Ishikawa H,Shimizu R,Park S,Kuriya N

更新日期：1991-01-01 00:00:00

abstract：:Blood ciclosporin (Cs) metabolite pattern in 58 liver grafted patients was routinely monitored by HPLC from the first Cs dose after transplantation until discharge from hospital. Eighteen patients with normal kidney function were allocated to Group I and 14 patients in Group II suffered Cs nephrotoxicity during their ...

journal_title：European journal of clinical pharmacology

authors： Christians U,Kohlhaw K,Budniak J,Bleck JS,Schottmann R,Schlitt HJ,Almeida VM,Deters M,Wonigeit K,Pichlmayr R

更新日期：1991-01-01 00:00:00

abstract：:Previous studies showed that probucol significantly lowered both LDL cholesterol and HDL cholesterol. In addition, there is evidence that as an essential antioxidant probucol causes variations in cellular interactions and cardiovascular functions in patients. Therefore, 14 hypercholesterolemic men were investigated be...

journal_title：European journal of clinical pharmacology

authors： Berg A,Baumstark MW,Frey I,Halle M,Keul J

更新日期：1991-01-01 00:00:00

abstract：:The pharmacokinetic behaviour of cefadroxil was dose-dependent in healthy male volunteers following the oral administration of single doses of 5, 15, and 30 mg.kg-1. As the dose of cefadroxil increased from 5 to 15 and 30 mg.kg-1, the peak plasma concentrations, normalized to 5 mg.kg-1, decreased significantly from 15...

journal_title：European journal of clinical pharmacology

authors： Garrigues TM,Martin U,Peris-Ribera JE,Prescott LF

更新日期：1991-01-01 00:00:00

abstract：:The influence of bezafibrate treatment on hepatic cholesterol metabolism was studied in rats and in humans. The activities of the three key enzymes involved in cholesterol metabolism [3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, cholesterol 7 alpha-hydroxylase, and acyl-coenzyme A: cholesterol acyltransf...

journal_title：European journal of clinical pharmacology

authors： Ståhlberg D,Reihnér E,Ewerth S,Einarsson K,Angelin B

更新日期：1991-01-01 00:00:00

abstract：:The pharmacokinetics of cefixime following a single oral dose of 200 mg have been investigated in 6 normal subjects and in 22 patients with various degrees of renal insufficiency. Serum and urine samples were collected between 0 and 72 h and were subjected to two methods of analysis: bioassay and HPLC. There was a lin...

journal_title：European journal of clinical pharmacology

authors： Dhib M,Moulin B,Leroy A,Hameau B,Godin M,Johannides R,Fillastre JP

更新日期：1991-01-01 00:00:00

abstract：:The peripheral histamine-inhibiting and central sedative effects of single oral doses (SOD) and of repeated administration for one week (steady state, SS), of 20 mg hydroxyzine HCL and 10 mg cetirizine have been assessed in 12 healthy volunteers, in a double-blind placebo-controlled cross-over study. Peripheral H1-rec...

journal_title：European journal of clinical pharmacology

authors： Levander S,Ståhle-Bäckdahl M,Hägermark O

更新日期：1991-01-01 00:00:00

abstract：:Jejunal perfusion was performed in 12 healthy volunteers to evaluate the dose dependent effects of loperamide on intestinal absorption, stimulated secretion and transit. In 6 volunteers intestinal perfusion of the jejunal segment with isotonic NaCl solution was followed by addition of loperamide in increasing doses (2...

journal_title：European journal of clinical pharmacology

authors： Press AG,Ewe K,Schmidt J,Junge H

更新日期：1991-01-01 00:00:00

abstract：:The pharmacokinetics of metoclopramide has been studied after acute IV administration to 12 patients with hepatic cirrhosis (6 with and 6 without ascites) and 6 control subjects. The elimination half-life was significantly longer in patients (11.4 h and 9.9 h in those with and without ascites, respectively, vs 6.4 h i...

journal_title：European journal of clinical pharmacology

authors： Albani F,Tamè MR,De Palma R,Bernardi M

更新日期：1991-01-01 00:00:00

abstract：:The systemic availability of oral zidovudine has been studied in 13 patients with the acquired immunodeficiency syndrome (AIDS) dosed either fasting or with breakfast. The mean peak plasma concentration and AUC of zidovudine were significantly 2.8- and 1.4-times higher in fasting patients than in those treated during ...

journal_title：European journal of clinical pharmacology

authors： Lotterer E,Ruhnke M,Trautmann M,Beyer R,Bauer FE

更新日期：1991-01-01 00:00:00

abstract：:Seventeen normotensive, premenopausal women were treated with the 5-hydroxytryptamine-reuptake inhibitor dexfenfluramine 30 mg per day, for 4 days in a randomised double-blind, cross-over, placebo controlled trial. Energy intake was held constant during the study as the aim was to study the endocrine and metabolic eff...

journal_title：European journal of clinical pharmacology

authors： Andersson B,Zimmermann ME,Hedner T,Björntorp P

更新日期：1991-01-01 00:00:00

abstract：:A randomized multicentre between-patient study comparison has been made of the efficacy and tolerability of cadralazine and prazosin, both administered for 6 weeks to hypertensive patients with a supine diastolic blood pressure (DBP) greater than or equal to 95 mmHg whilst on a beta-adrenoceptor-blocker. The doses of ...

journal_title：European journal of clinical pharmacology

authors： Caponnetto S,Valvo E,Mocarelli P,Alberti D,Savonitto S

更新日期：1991-01-01 00:00:00

abstract：:In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg.100 ml-1) was significantly...

journal_title：European journal of clinical pharmacology

authors： Chauhan BL,Kulkarni RD

更新日期：1991-01-01 00:00:00

abstract：:In 10 healthy male subjects the pharmacokinetics and haemodynamic effects of sustained-release isosorbide-5-mononitrate 60 mg (IS-5-MN) were studied after oral administration at two different times in the day (08.00 h and 20.00 h). Effects on blood pressure and heart rate after 3 min standing upright were measured in ...

journal_title：European journal of clinical pharmacology

authors： Lemmer B,Scheidel B,Blume H,Becker HJ

更新日期：1991-01-01 00:00:00

abstract：:The effects of a 10 day administration of clomipramine (25-50 mg t.i.d.), alprazolam (0.25-0.75 mg t.i.d.) and placebo were assessed in normal volunteers in a double-blind cross-over study. A battery of physiological, psychomotor and cognitive tests was administered both before and 3 h after drug on days 1, 5 and 10. ...

journal_title：European journal of clinical pharmacology

authors： Allen D,Curran HV,Lader M

更新日期：1991-01-01 00:00:00

abstract：:The anti-ischaemic properties of nimodipine 30 mg and 60 mg t.i.d. for 4 days has been tested in a double-blind, placebo-controlled, cross-over study based on the use of hyperventilation to reduce flow velocity in cerebral arteries. Whether the anti-ischaemic properties were due to a vasodilatator action on cerebral b...

journal_title：European journal of clinical pharmacology

authors： Kraaier V,van Huffelen AC,Wieneke GH,Hesselink JM

更新日期：1991-01-01 00:00:00

abstract：:Dopamine is frequently used in critically ill newborn infants for treatment of shock and cardiac failure, but its pharmacokinetics has not been evaluated using a specific analytical method. Steady-state arterial plasma concentrations of dopamine were measured in 11 seriously ill infants receiving dopamine infusion, 5-...

journal_title：European journal of clinical pharmacology

authors： Bhatt-Mehta V,Nahata MC,McClead RE,Menke JA

更新日期：1991-01-01 00:00:00

abstract：:The debrisoquine hydroxylation phenotype was studied in 152 unselected healthy Tasmanian subjects, who were mostly Caucasians of British ancestry. Following a 10 mg oral dose of debrisoquine (D), the ratio of D/4-hydroxydebrisoquine excreted in 8-h urine (metabolic ratio, MR) was determined. MR values were bimodally d...

journal_title：European journal of clinical pharmacology

authors： Veronese ME,McLean S

更新日期：1991-01-01 00:00:00

abstract：:General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension. 128 patients with primary hypertension were included from 10 participating centres. The patients were ra...

journal_title：European journal of clinical pharmacology

authors： Dahlöf C,Hedner T,Thulin T,Gustafsson S,Olsson SO

更新日期：1991-01-01 00:00:00

abstract：:In eight patients with uncomplicated non insulin dependent diabetes mellitus, serum insulin levels, serum C-peptide levels and blood glucose levels were measured before and after oral administration of glibenclamide 0.1 mg/kg body weight and a test meal, or after a test meal alone. The rise in serum insulin levels per...

journal_title：European journal of clinical pharmacology

authors： Mulder H,Schopman W Sr,van der Lely AJ

更新日期：1991-01-01 00:00:00

abstract：:The effects of S-422 (1-(3-trifluoromethylphenyl)-2-[N-(2-hydroxyethyl) amino] propane), an hepatic metabolite of the hypolipidaemic drug Benfluorex, on lipid metabolism have been investigated in two experimental models: in human fetal lung fibroblasts, for study of the apo B/E receptor-mediated regulation of choleste...

journal_title：European journal of clinical pharmacology

authors： Mazière JC,Mazière C,Auclair M,Mora L,Arnaud O

更新日期：1991-01-01 00:00:00

abstract：:A 8.5-month prospective study was performed in the Rhône area of France to study the incidence of infectious diseases in children in day care, and the qualitative and quantitative aspects of drug prescriptions for young children. The families of 1.359 children agreed to participate (98.5% of those selected). During th...

journal_title：European journal of clinical pharmacology

authors： Collet JP,Bossard N,Floret D,Gillet J,Honegger D,Boissel JP

更新日期：1991-01-01 00:00:00

abstract：:In 6 normal volunteers given single oral doses of 250,500 and 1000 mg ticlopidine (T), the peak plasma level of unchanged drug was reached after about 2 h. There was no correlation between the plasma T level and its inhibitory effect on platelet function, expressed as % inhibition of ADP-induced aggregation. By means ...

journal_title：European journal of clinical pharmacology

authors： DiPerri T,Pasini FL,Frigerio C,Blardi P,Centini F,Messa GL,Ghezzi A,Volpi L

更新日期：1991-01-01 00:00:00

abstract：:The pharmacokinetics of a single 2 mg IV dose of chlordesmethyldiazepam has been studied in 11 patients with renal failure on regular haemodialysis and in 11 age-matched healthy controls. The kinetics was also examined after a single 2 mg oral dose in 6 of the 11 renal failure patients. After intravenous administratio...

journal_title：European journal of clinical pharmacology

authors： Sennesael J,Verbeelen D,Vanhaelst L,Pirola R,Bareggi SR

更新日期：1991-01-01 00:00:00

abstract：:A phamacokinetic study in man has been made of a new dosage form of diclofenac hydroxyethylpyrrolidine (DIEP); soluble salt packed in sachets was compared with diclofenac sodium as enteric coated tablets. Oral DIEP 2 X 50 mg showed a significant difference in absorption kinetics (ka, lag time and tmax) as compared to ...

journal_title：European journal of clinical pharmacology

authors： Maggi CA,Lualdi P,Mautone G

更新日期：1990-01-01 00:00:00

abstract：:Postural and isometric handgrip tests were performed on nine patients with panic disorder and 13 patients with major depression before and after treatment with imipramine for a mean duration of 10 weeks. There were significant increases in resting supine heart rate (HR), systolic, diastolic and mean blood pressures (S...

journal_title：European journal of clinical pharmacology

authors： Yeragani VK,Meiri P,Balon R,Pohl R,Golec S

更新日期：1990-01-01 00:00:00

abstract：:In this paper pharmaceutical and biopharmaceutical aspects on the development of long-acting nitrate delivery systems are reviewed. Basic considerations and requirements are also discussed. Recent product development activities are presented, with an emphasis on nitroglycerin in transdermal form and oral isosorbide-5-...

journal_title：European journal of clinical pharmacology

authors： Jonsson UE

更新日期：1990-01-01 00:00:00

abstract：:Tolbutamide (1 g/70 kg) was administered as a single intravenous dose to 31 healthy, non-smoking, drug-free males between 23 and 87 years old and the total amounts of hydroxy and carboxytolbutamide excreted in 24 h were measured. There was a significant decrease in the urinary recovery of both metabolites with age. Th...

journal_title：European journal of clinical pharmacology

authors： Miller AK,Adir J,Vestal RE

更新日期：1990-01-01 00:00:00

abstract：:1. The effect of pre-dosing with 15 mg domperidone, a relatively selective dopamine 2-receptor antagonist, on the ocular hypotensive action of a single oral dose of 25 micrograms pergolide, a dopamine 2-receptor agonist, was studied in 9 normal human volunteers, using a non-invasive method. 2. Compared with domperidon...

journal_title：European journal of clinical pharmacology

authors： al-Sereiti MR,Quik RF,Hedges A,Turner P

更新日期：1990-01-01 00:00:00

abstract：:The linearity of the pharmacokinetics of the metamizol metabolites 4-methyl-amino-antipyrine (4-MAA), 4-amino-antipyrine (4-AA), 4-formyl-aminoantipyrine (4-FAA), and 4-acetyl-amino-antipyrine (4-AcAA) has been studied after administration to 15 healthy male volunteers of single oral doses of 750, 1500, and 3000 mg me...

journal_title：European journal of clinical pharmacology

authors： Vlahov V,Badian M,Verho M,Bacracheva N

更新日期：1990-01-01 00:00:00